A mathematical model of the mitochondrial NADH shuttles and anaplerosis in the pancreatic -cell
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چکیده
Pål O. Westermark, Jeanette Hellgren Kotaleski, Anneli Björklund, Valdemar Grill, and Anders Lansner Parallel Scientific Computing Institute/Computational Biology and Neurocomputing, Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden; Institute for Theoretical Biology, Humboldt University Berlin, Berlin, Germany; Department of Molecular Medicine, Endocrine and Diabetes Unit, Karolinska Institute and Hospital, Stockholm, Sweden; and Institute of Cancer Research and Molecular Medicine, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
منابع مشابه
A mathematical model of the mitochondrial NADH shuttles and anaplerosis in the pancreatic beta-cell.
The pancreatic beta-cells respond to an increased glycolytic flux by secreting insulin. The signal propagation goes via mitochondrial metabolism, which relays the signal to different routes. One route is an increased ATP production that, via ATP-sensitive K(+) (K(ATP)) channels, modulates the cell membrane potential to allow calcium influx, which triggers insulin secretion. There is also at lea...
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تاریخ انتشار 2007